Set to take place consecutively between 13:00 and 14:00, the plane’s appearances will consist of a ‘fly-past’ at both airports followed by a cruise along Liverpool’s waterfront.
Weather permitting, the A380 will then follow the River Mersey and make an appearance at the Wirral Show.
Some 200,000 people are expected to attend the Wirral Show and they will witness a special flying display by the A380.
Behind the controls will be Peter Chandler, a former RAF pilot and ex-Virgin Atlantic captain, who said: "It is a great privilege to be able to bring the A380 to the north-west and to show it off for the first time at the region’s international airports.
"We are especially keeping our fingers crossed for good weather over the Wirral in order to fully demonstrate how versatile, quiet and manoeuvrable this wonderful aircraft is."
This weekend’s appearances will be something of a homecoming for the A380, as its wings are produced at the Airbus UK site near Chester and many of its 7,000-strong workforce are residents of north-west England.