Manchester Airport has recently waved off an inaugural TAP Portugal flight on its way to the Portuguese capital, Lisbon.
The airline is currently operating six flights from the Manchester travel hub to the Portuguese city every week.
Passengers can now use the Manchester-Lisbon link to access global business destinations, such as Dakar, Brasilia and Luanda.
Over the coming months, 15,000 customers are booked on the new service and the June 1st service boasted a 75 per cent load factor.
Andrew Harrison, managing director of Manchester Airport, said: "Having TAP Portugal announce a route to Lisbon from Manchester will not only give passengers access to Portugal's capital city but TAP are also one of the largest carriers of passengers to South America from Europe and that opens even more destinations to our customer base in the north-west."
He added that the new route was sure to be popular with passengers.
One-way fares begin from £55 including taxes, as well as frequent flyer miles and onboard snacks and drinks.
Passengers using Manchester Airport can also reach a number of other countries throughout Europe, including Spain, Germany, Italy, Switzerland and Austria.